Background and Objective:Enteric fever, often known as typhoid and paratyphoid fever, is a potentially fatal disease caused by Salmonella serotypes Typhi and Paratyphi, respectively. In developing and impoverished nations, it is a serious public health concern.This study aims to evaluate antibiotic resistance patterns and compare the automated blood culture system against the traditional blood culture method.Material method: The current study was conducted in the Mahatma Gandhi Memorial Medical College's microbiology department in Indore, Madhya Pradesh, central India, between 2020 and 2021. Blood samples from suspected enteric fever cases were received by the microbiology department. Twenty-six isolates of salmonella species were identified from 140 blood samples; these isolates were included in the study. Antimicrobial susceptibility testing was performed for all isolated organisms on Mueller-Hinton agar by the Kirby-Bauer disc diffusion method as per CLSI M100 2020 guidelines.Result: This study involved the collection of blood in BHI broth for the purpose of culture, as well as the testing of antibiotic sensitivity in 140 clinically suspected cases of enteric fever that were received by the Department of Microbiology at M.G.M. Medical College, Indore. 26 Salmonella enterica strains that were culture-positive were isolated and identified out of the 140 blood culture samples that were received.Conclusion: Salmonellosis is still a concern for public health. It is imperative to fortify preventative measures, enhance low-income nations' access to diagnostic resources, and encourage careful administration of antibiotics.