Most patients undergoing surgery using spinal anesthesia experience perioperative anxiety. Anxiety can affect patient well-being and trigger a physiological stress response that can have a negative impact on surgery. One way to deal with perioperative anxiety is with non-pharmacological therapy, one of which is Immersive Virtual Reality technology. The use of IVR technology in healthcare contexts has shown potential in reducing anxiety and stress responses in patients. Adrenaline and noradrenaline as stress hormones are involved in the body's response to stressors. Measuring adrenaline and noradrenaline levels can be used as an indicator of anxiety and stress. Aim: This study aims to ascertain the impact of employing IVR in diminishing the stress response, as indicated by the levels of plasma adrenaline and noradrenaline, among patients undergoing surgery with the subarachnoid block anesthesia technique. Material and Methods: Analytical study, experimental single blind randomized control trial. A total of 30 subjects aged 18-45 years, who underwent caesarean section surgery using subarachnoid block anesthesia technique, were randomly divided into two groups, the intervention group would be given IVR experience and the control group would not be given IVR experience. Both groups were examined for baseline and evaluation adrenaline and noradrenaline levels, and tested statistically. Results: Statistical tests showed a significant difference in evaluation adrenaline levels (intervention group 45.86 ± 11.40 pg/mL and control group 70.80 ± 37.17 pg/mL p=0.019) and a significant difference in evaluation noradrenaline levels (intervention group 134.2 ± 34.5 pg/mL). and control group 164.2 ± 36.6 pg/mL p=0.029). Conclusion: Baseline adrenaline levels in the two groups were not statistically significantly different. Evaluation adrenaline levels in the two groups had statistically significant differences. Initial noradrenaline levels in the two groups were not statistically significantly different. Evaluation noradrenaline levels in the two groups had statistically significant differences.