A comparative cross-sectional observational survey at the University of Lahore explored the quality of life (QoL) of parents of children with cerebral palsy. Data from 223 parents (mean age: 33.95 ± 5.01 years) and their children (mean age: 6.31± 3.55 years) indicated that 49.7% were male and 50.2% were female. About 10.8% reported having children with other disabilities. Both mothers and fathers rated their QoL similarly, with no statistically significant difference (p= .154). Among male respondents, 10.31% rated very poor, 28.25% poor, 4.48% normal, and 6.72% good. Among females, 11.21% rated very poor, 31.39% poor, 4.04% normal, and 3.59% good. The findings suggest that while both parents face challenges, nuances exist in their experiences. Mothers, often primary caregivers, report higher levels of stress, emotional burden, and limitations in daily activities compared to fathers. This reflects the broader impact of caregiving responsibilities on maternal QoL. The study highlights the need for targeted support and interventions to address the specific needs of both mothers and fathers of children with cerebral palsy, aiming to enhance their overall well-being and coping mechanisms.