Background: Helicobacter pylori (H. pylori) infection represents a widespread health concern globally, impacting over half of the population. It is closely linked to various gastrointestinal conditions, such as chronic gastritis, peptic ulcer disease, and gastric cancer. Typically, the standard treatment for H. pylori infection involves a combination of antibiotics and proton pump inhibitors (PPIs) to improve eradication rates. Nevertheless, the increasing resistance to antibiotics has significantly challenged the effectiveness of traditional treatment regimens, prompting the investigation of alternative therapeutic approaches. One such approach is reverse hybrid therapy, which involves the sequential administration of antibiotics. In contrast, concomitant therapy administers all antibiotics simultaneously, aiming for a broader antibacterial effect and enhanced patient compliance. This study aims to compare the efficacies of reverse hybrid therapy and concomitant therapy in treating H. pylori infection within a tertiary hospital setting.