The conservation of endangered marine mammals is a pressing concern, necessitating a comprehensive understanding of their population structure and genetic diversity. This study aims to elucidate the genetic dynamics of endangered marine mammals, focusing on how these factors can inform effective management strategies. We employed a multi-faceted approach, combining mitochondrial DNA analysis, microsatellite markers, and genome-wide single nucleotide polymorphism (SNP) data to assess genetic variation and population differentiation among several endangered marine mammal species. Our findings reveal significant genetic structuring within and between populations, indicating limited gene flow and potential barriers to dispersal. The levels of genetic diversity varied among species, with some populations exhibiting alarmingly low diversity, which could compromise their adaptive potential and long-term viability. These results underscore the importance of maintaining genetic diversity to enhance resilience against environmental changes and anthropogenic pressures. To translate these genetic insights into practical conservation measures, we propose a suite of management strategies tailored to the specific genetic profiles of each species. These include the establishment of marine protected areas (MPAs) to safeguard critical habitats, the implementation of translocation programs to boost genetic diversity in isolated populations, and the enhancement of international collaboration for coordinated conservation efforts. Our study highlights the critical role of conservation genetics in informing the management of endangered marine mammals. By integrating genetic data with ecological and behavioral information, we can develop more effective and adaptive management strategies that promote the long-term survival of these vulnerable species. This research underscores the need for ongoing genetic monitoring and adaptive management to ensure the persistence of marine mammal populations in the face of ongoing environmental challenges