Dental caries is the most common dental disease with high prevalence. Dental caries is multifactorial disease and it is crucial to assess the association of dental caries with various factors which is essential in rendering the treatment required along with spreading awareness regarding to its prevention Objectives: To find the correlation between dental caries in relation to different blood groups among 12-15 years school going children. Methods: The present study was conducted amongst 12-15 yrs age school going children in Bilaspur city. A total of 335 children participated in the study. A prior consent was taken from their parents for the study. All the children were asked to give their blood group data along with parent consent form. The dental caries status was recorded. Descriptive analysis and chi square test were used to find any correlation between blood groups and dental caries. Probability level was fixed at <0.05. Results: Out of 730 school students, 335 had dental caries. Among 335 , 23.25% had blood group A, 28.1% had blood group B, 15.5% had blood group AB, and 33.15% had blood group O. There was a strong correlation found with blood group B and O with dental caries which was statistically significant (Table 3). Conclusions: There is a correlation existing between dental caries and blood groups. The prevalence of blood group B is more in this geographic location, followed by blood groups O and A, and the least prevalent was blood group AB. There was an increased prevalence of carious lesions among subjects of blood group O followed by blood groups B and A. This association between caries and blood groups O, B and A can be due to various blood group antigens acting as receptors for infectious agent associated with dental disease.