Background: This study explores the correlation between malocclusion, periodontal health, and temporomandibular disorders (TMD) from a public health perspective. Given the increasing prevalence of dental misalignment and associated complications, understanding these relationships is crucial for preventive and therapeutic interventions. Methods: A cross-sectional study was conducted at Women Medical and Dental College from January 2023 to January 2024, involving 79 participants. Clinical examinations were performed to assess malocclusion using Angle’s classification, periodontal health through plaque index, gingival index, probing pocket depth, and clinical attachment loss, and TMD symptoms based on joint tenderness, clicking, deviation, and muscle pain. Lifestyle factors, including stress, oral hygiene habits, and parafunctional activities, were also recorded. Statistical analysis was conducted using SPSS, with chi-square and independent t-tests to determine significant associations. Results: The findings revealed a significant correlation between malocclusion and both periodontal health and TMD (p<0.05). Crowding and crossbite were particularly associated with increased plaque accumulation and periodontal deterioration. Participants with severe malocclusion were also more likely to report TMD symptoms, including joint pain and clicking. Additionally, periodontal disease, characterized by deep pockets and attachment loss, was linked to TMD, suggesting that chronic inflammation may contribute to jaw dysfunction. Stress and parafunctional habits were found to further aggravate these conditions. Conclusion: Malocclusion, periodontal disease, and TMD are closely interrelated, with each factor potentially worsening the other. Early diagnosis, preventive dental care, and multidisciplinary treatment approaches are essential in managing these conditions effectively. Addressing malocclusion through orthodontic treatment, improving periodontal health, and reducing risk factors like stress and parafunctional habits can significantly contribute to better oral health outcomes.