Curcumin is a naturally occurring hydrophobic molecule and considered to be therapeutically safe.it is a naturally present polyphenolic compound, belonging to class of flavonoids glycosides. It is also known as diferuloylmethane and has been widely studied for its therapeutic efficacy for many disorders including several inflammatory diseases. However its application is highly restricted due to its poor aqueous solubility, physicochemical instability and inadequate bioavailability.It has anti-inflammatory, antioxidant, anticarcinogenic and antiinfectious properties. The objective of the present study is to formulate curcumin-phospholipid complex and characterize by physicochemical method. Curcumin-loaded phytosomes were prepared by thin film hydration method using rotary evaporator by using soya-lecithin as a phospholipid. The formulation was prepared with a variable drug: soya-lecithin ratios (0.5–2.5), with varying temperature (45–650C). Design expert software was used for the optimization of Curcumin-loaded phytosomal formulations. Central composite design-based factorial design was applied and evaluated for percentage yield and entrapment efficiency as dependent variables. The effects of drug- phospholipid complex and temperature on percentage yield and entrapment efficiency were studied graphically. The formulations were further characterized with vesicle size, zeta potential and in-vitro release. In-vitro drug release study showed that a maximum of about 90.83% drug was released from the Curcumin-phytosomal formulation at the end of 12 hr. FT-IR analysis, DSC techniques were used to evaluate the drug and soya-lecithin compatibility studies. Scanning electron microscopy showed the uniform structure and spherical shape of the vesicles. Theresults of the study revealed that the Curcumin-soya-lecithin phytosomecomplex may be considered as apromising drug delivery system that improves the absorption and bioavailability of plantconstituents.