The popularity of watermelon, Citrullus lanatus (Cucurbitaceae) has increased in recent years in Cameroon due to the important nutrients it contains and health benefits it presents. Inspired by the ethno botanical and ethno medicinal uses of watermelon, this study was designed to evaluate its cytogenotoxic properties using the spermatogonial germ-line cells of the grasshopper Zonocerus variegatus L. (Orthoptera: Pyrgomorphidae).