In order to prevent and treat dental plaque, dental caries, and periodontitis, the current study aims to formulate and evaluate a herbal mucoadhesive antimicrobial dental gel using Lantana camara Linn’sroots extract. The disintegration of teeth caused by acid, produced by bacteria such as Streptococcus mutans is known as tooth decay, dental caries, or cavity. Globally, dental caries has been the most prevalent issue related to oral health. Dental caries is characterized as a pathological process of external origin that is confined, post-eruptive, and involves weakening of the hard tooth tissue before a cavity form. The extract from the roots of Lantana camara Linn is obtained by maceration process with solvent ethanol and water (60:40 v/v). TheFolin-Ciocalteu spectrophotometric technique was used to determine the extract’s total phenolic content. Using polyethylene glycol (PEG) 400 as a penetration enhancer and carbopol 934 as a bioadhesive polymer, a mucoadhesive gel was formulated. Several characteristics, including appearance, pH, viscosity, spreadability, and in vitromucoadhesion studies, were assessed for the dental gel formulation. Using the disc diffusion method, the dental gel’s antibacterial activity against Streptococcus mutans was tested on Mueller Hinton agar media. Additionally, a stability study spanning a month is examined. The Mucoadhesive Dental gel of L. camara roots extract has the desired qualities in terms of color, odor, consistency, grittiness, uniformity, stickiness, and homogeneity, according to the results of a physiochemical evaluation research. The developed oral gel's assessment criteria show that it is a mucoadhesive, stable, and effective drug delivery system that contains antimicrobial phytoconstituents to prevent periodontitis, tooth caries, and plaque development.