The disease is characterized by elevated thrust levels, hunger, and urination. The leading cause of developing this disease is the production of insufficient insulin by the pancreas. There are two major categories of diabetes mellitus found: one is insulin dependent diabetes mellitus (IDDM), and another is noninsulin dependent diabetes mellitus (NIDDM).Using AutoDock Vina v1.5.7 and the CHARMm bas ed docking tool CDOCKER from Discovery Studio Client v20.1.0.19295, molecular docking simulations were performed to examine the binding interactions of the synthesized compounds within the target protein 5TT0's active site. All the four compounds having th e capability to bind towards the PPAR γ receptors and showing the better ADMEt results while checking through swiss ADME These compounds can be further synthesized in the laboratory and tested for their PPAR γ binding activity