OBJECTIVE:The objective of the study was development, evaluation of theLamivudine floating tablets with natural polymers Method: Lamivudine floating tablets were developed by physical method ofcompression using Guar Gum and Xanthane gum as Natural polymers and Sodium bicarbonate. The tablet formulations are developed and assessed for physicochemical parameters, floating study, drug content, dissolution,Kinetic models and stability studies. Results: The obtainedresultswerefollowed within the suitable limits for all formulations and among all the formulations F4 shown the good floating behaviour, better drug release. The formulation (F4) was follows Higuchi kinetics and it was more stable at various temperature conditions. Conclusion: Lamivudine floating tablets were developed successfully by natural polymers and were stable for three months.