Zaltoprofen and Cataflam are the NSAIDs category of drugs which could be used for the Arthritis for pain management. These are COX2 inhibitors, basically interfere with the prostaglandin synthesis and thus are able to reduce the sensation of pain in joints. Orally in the form of tablets or any other dosage forms, desired action could not be achieved hence here an attempt is being made to prepare nano formulation of these anti arthritic agents by using Spray Drying technique with the help of Spray Dryer. The formulations were prepared by using aqueous dispersion method by using HPMC and SLS in the concentration 0.5 % and 1% respectively. Initially 8 batches were prepared and checked for zeta potential as well as particle size. To check the crystallinity selected batch F3, F7 & F8 were sent for XRD analysis, which confers the crystalline nature of the formulations