A number of novel 2-aryl substituted benzothiazoles were created for the current investigation, and their ability to suppress the growth of Mycobacterium TB H37Rv strain of the bacteria was assessed. FTIR and NMR spectral analysis were used to characterise the structures of the newly synthesised substances. The majority of the synthetic molecules exhibited good to moderate anti-tubercular efficacy. According to the findings, three compounds—3a, 3d, 3f, and 3g—have antitubercular activity that is either superior to or equal to that of ordinary streptomycin and pyrazinamide. Benzothiazoles should be given further thought as potential antitubercular drugs based on future research.