Desquamative gingivitis (DG) is a descriptive clinical term signifying epithelial detachment of the oral masticatory mucosa, presenting as "peeling gums." this usually manifests as a sign and symptoms rather than a distinct disease entity, often associated with various underlying mucocutaneous conditions. Accurate diagnosis necessitates a meticulous clinical evaluation, encompassing a comprehensive medical history and lesional biopsy with histopathological examination, and potentially sometimes more specialized investigations such as direct and indirect immunofluorescence assays. Treatment for DG centers on addressing the underlying disease and etiology which may frequently requires the administration of immunosuppressive medications, such as corticosteroids. Furthermore, meticulous oral hygiene practices to eliminate local gingival irritants, including dental plaque and calculus, can significantly enhance treatment outcomes.