Background: Helicobacter pylori (H. pylori) is a small, spiral-shaped bacterium that lives in the surface of the stomach and duodenum. More than half of the world’s population is colonized with H. pylori in the gastric mucosa which is the major cause of chronic gastritis, peptic ulcer and also the most important etiological factor responsible for the duodenal and gastric ulcer and has an important role in the pathogenesis leading to gastric cancer.