ISSN : 2663-2187

DEVELOPMENT AND CHARACTERIZATION OF EMULGEL FOR TOPICAL APPLICATION

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Mr. Shaikh Khalil K.2, Mr. Swami Avinash B.1*, Mr. GadaSheshgiri N.2, Ms. AgwaneShantaG.3,Ms. DhumalLata S.4
ยป doi: 10.48047/AFJBS.6.5.2024. 9489-9493

Abstract

In the present study, an attempt has been made to develop the topical drug delivery system of fluconazole as Emulgel. Fluconazole is an antifungal medicine used to treat a variety of fungal skin infections. When taken by mouth, this medication has a low absorption rate. To counter this, topical drug delivery is favored, as it prevents the drug's first-pass metabolism. Emulgel of Fluconazole was prepared by the emulsification technique using gelling agent carbapol 940; Span 20 and tween 20 as Emulsifiers; Propylene glycol as penetration enhancer; Methyl paraben used as preservative. The major objective behind this formulation is to enhance topical delivery of Fluconazole which is hydrophobic in nature.The prepared emulgel were evaluated for their physical appearance, viscosity, spread-ability, % drug diffusion and drug content. Physical characteristics of all the prepared emulgels were acceptable. % Drug diffusion reveals a maximum release of 96.4 percent in 4 hours and the drug content was found to be 88.59 in F9 formulations. When compared to all other formulations, the formulation batch F9 shows better drug release. The formulation was found to be stable over the stability period.From the study conducted, it can be concluded that emulgel of Fluconazole can be better alternative for conventional topical gel. However thorough clinical studies need to prove its actual human use.

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