Azolsartan medoxomil solid dispersions based on polyvinylpyrrolidone were developed and analyzed in this study to improve their solubility and dissolution rate in water. The investigation encompasses the utilization of both solvent evaporation and kneading techniques for solid dispersion preparation. Results indicate that solid dispersions produced through the solvent evaporation method exhibit superior enhancements in solubility compared to those prepared via kneading. Notably, among the tested formulations, B3, formulated with a drug-to-carrier ratio of 1:0.5 using solvent evaporation, demonstrates a notable four-fold increase in aqueous solubility. Solid dispersion technology is expected to boost azilsartan medoxomil formulations' bioavailability and therapeutic effectiveness. Further refinement of formulation parameters could yield optimized drug delivery strategies, potentially enhancing treatment outcomes for hypertension and associated conditions.