The main objective of present study is to formulate and evaluate floating microspheres of Verapamil hydrochloride for treating hypertension. Verapamil hydrochloride is an effective antihypertensive drug but it undergoes hepatic first pass metabolism. Its half-life (t1/2) is 2-5 hrs and it should be administered 3-4 times to maintain plasma drug concentration. So, it requires control release of a drug. Hence an alternative drug delivery system is needed for increasing therapeutic efficacy, reducing the dosing frequency of drug and improving its half-life and bioavailability. Therefore, it is necessary to develop a newer formulation which releases the drug in a sustained release manner. Floating microspheres loaded with Verapamil hydrochloride were prepared using ionic gelation method using sodium alginate in different ratios. Sodium alginate as Microsphere core forming agent, calcium carbonate as Gas generating agent, and Calcium chloride as Cross inking agent were used for the formulation of Verapamil hydrochloride floating Microsphere. Preformulation studies like drug excipient compatibility studies, Particle size, particle shape, flow properties were carried out. Invitro buoyancy, Invitro dissolution studies, Entrapment efficiency and Drug content were performed. Preformulation studies for Verapamil hydrochloride loaded hollow microspheres demonstrated that all formulations exhibit good flow properties. SEM analysis demonstrated that the surface of hollow microspheres was smooth and spherical in shape. FTIR spectra studies displayed that there is no incompatibility between drug and excipients. Optimization of formulations done by maximum amount of drug release within 12h and buoyancy studies. Based on the results of invitro drug release studies it was found that F7 formulation has shown Sustained drug release for 12h with zero order drug release. Hence the optimized formulation (F7) of Verapamil hydrochloride hollow microspheres shows good potential for novel treatment of hypertension