The objective of this work was to develop and evaluate multiparticulate pulsatile drug delivery for the chronotherapeutic delivery of Azelnidipine. The drug loaded pellets was prepared by solution layering technique using PVP K-30 (2%) as binder. The drug loaded nonpareil beads were coated with polymer solution mixture of (Eudragit RS 100 and RL 100) at different composition using triethyl citrate (TEC) as a plasticizer and talc antisticking agent in a mixture of IPA: DCM (7:3). The prepared pellets were then evaluated for FTIR, Flow properties, friability, drug content, SEM and in vitro dissolution study. FTIR study reveals no interaction between drug and polymer. SEM study confirmed the smooth appearance of coating over the surface of pellets. Pellets coated with 10% polymer coating weight gain showed promising lagtime and delay drug release. Batch F6 prepared with 60:40 ratio of eudragit RS and RL 100 polymer gives total lag time of 4hrs and drug release of 96.23±5.41% in 8 hr. Further optimized coated pellets formulation was evaluated for pharmacokinetics study. In vivo study also confirmed the delay appearance of drug in plasma after considerably long lag time. This study concludes that solution layering technique followed by coating with combination of eudragit polymer can be used for the development of multiparticulate drug delivery system for the chronotherapeutics management of hypertension.