Malaria, caused by parasites transmitted through Anopheles mosquitoes, remains a significant global health concern, with substantial morbidity and mortality rates. This review explores the development and evaluation of phytosomes as a promising approach for malaria treatment. Phytosomes, encapsulating hydrophilic bioactive phytoconstituents within phospholipid complexes, offer enhanced drug delivery and bioavailability compared to traditional herbal extracts. Various methods, including solvent evaporation, mechanical dispersion, and anti-solvent precipitation, are employed for phytosomes preparation. Evaluation techniques such as scanning electron microscopy, dynamic light scattering, and spectrophotometry are utilized to assess their characteristics and efficacy. Furthermore, challenges, future directions, and the role of phytosomes in malaria treatment are discussed, highlighting their potential as a novel therapeutic strategy.