ISSN : 2663-2187

DEVELOPMENT AND VALIDATION OF ROBUST RP-HPLC METHOD FOR QUANTITATION OF DEXTROMETHORPHAN HBr, PHENYLEPHRINE HCl, CHLORPHENIRAMINE MALEATE IN PHARMACEUTICAL DOSAGE FORM

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Shweta Bhagwat , Rahul Buchade, Pradnya Swami
ยป doi: 10.33472/AFJBS.6.10.2024.4136-4154

Abstract

Dextromethorphan hydrobromide suppresses cough reflex centrally, Phenylephrine HCl constricts nasal blood vessels to ease congestion, and Chlorpheniramine maleate relieves allergy symptoms. In that, mobile phase comprised a phosphate buffer at pH 3.2, Acetonitrile and Methanol. Detection was achieved using a UV-Visible detector at 220 nm, with a flow rate maintained at 1.0 ml/min.

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