The nonsteroidal anti-inflammatory medicine (NSAID) aceclofenac has a low absorption rate, which limits its bioavailability. By employing piperine as a bioavailability enhancer, this study attempted to design, optimize, and assess Aceclofenac tablets. Tablets containing different amounts of piperine (0.5-2%) were made using a solvent evaporation technique. When comparing the dissolution rate and bioavailability of the optimized formulation (F3) with 1% piperine to the conventional formulation, the former shown improvements. Superior analgesic and anti-inflammatory properties were shown in both in vitro and in vivo tests. With respect to the standard formulation, the bioavailability of the improved tablets increased by a factor of 2.5. With piperine's potential to increase Aceclofenac's bioavailability and improve therapeutic efficacy, this study provides evidence for its use.