NEP advocates for multidimensional exploration of concepts, prompting scholars to delve into the biological roots of neurotic disorders and their behavioral ramifications, thus inspiring empirical research by experts. Neurotic disorders, characterized by distressing emotional states and maladaptive coping mechanisms, pose significant challenges to mental health. This paper explores the historical and contemporary perspectives on the biological foundations of neurotic disorders, with a focus on abnormal behavior within this framework. Early proponents like Haller and Kraepelin emphasized brain pathology's role, paving the way for modern biological viewpoints. Behavior genetics research reveals hereditary influences, while biochemical imbalances, notably dopamine dysregulation, contribute to neurotic disorders. Biophysical therapies such as electroconvulsive therapy underscore the biological underpinnings of mental illnesses. Examining specific disorders like phobia, panic disorder, generalized anxiety disorder (GAD), and obsessive-compulsive disorder (OCD), genetic predispositions, autonomic nervous system dysregulation, and neurological abnormalities emerge as key factors.