This research focuses on conducting a Drug Utilization Evaluation (DUE) to assess the current prescribing patterns and medication utilization for dermatological conditions and explores the pivotal role of clinical pharmacists in improving patient psychological compliance, and overall quality of life through comprehensive pharmaceutical care. Methodology: This study is a prospective observational study involving 110 patients affected with dermatological conditions who underwent treatment at the tertiary care hospital Maharaja Institute of Medical Sciences hospital in Vizianagaram district. The information was obtained through direct interaction with dermatology patients. Results: In the study, we reported a prevalence of 25% psoriasis cases among the study population with itching and lesions. Antihistamines followed by antibiotics were notable for being the most frequently prescribed type of medication. Patients, who encounter multiple recurrences, comprising 42% of cases, tend to exhibit lower quality of life and increased severity of depression levels compared to those experiencing a single occurrence. Conclusion: Patients who suffer from multiple recurrences, accounting for 42% of cases, are found to have a diminished quality of life and more severe levels of depression compared to those experiencing a single occurrence which also includes psoriasis at the highest prevalence rate.