Ankle sprains are among the most common recurrent injuries of the lower extremity. Blood flow restriction (BFR) training can provide a more effect to low-load training. The present study aimed to study the effect of blood flow restriction and proprioception training on muscle strength and ankle abilities in recurrent ankle sprain patients. Material and methods: 34 patients participated in this study, randomly assigned to two groups. Control Group received conventional therapy only. Experimental Group received conventional therapy, blood flow restriction and proprioception training. Peak torque of dorsiflexors and planter flexors were measured by isokinetic dynamometer, physical function by Foot Ankle Ability Measure. Results: MANOVA was carried out to test the impact of treatment. Dorsi- flexor peak torque at 60 post study revealed that, there was significant difference between the two groups (P = 0.001) and at 180 there was significant difference between them (P = 0.001), in favor to experimental group. Planter flexor peak torque at 60 and 180 post study revealed that, there was significant difference between groups (P = 0.001), in favor to experimental group. Foot Ankle Ability Measure post study revealed that there was significant difference between groups (p=0.001) in favor to experimental group. Conclusions: Low load blood flow restriction training combined with proprioception training enhanced muscle strength and ankle abilities in unilateral recurrent ankle sprain patients. There was a positive clinical important improvement, post compared with the pre study