Background: Vitiligo, is a chronic disease manifested by partial or total loss of melanocytes with impaired quality of life (QoL) Aim: explore the effect of educational program about health promotion on vitiligo patients' quality of life. Methods: The study involved 55 vitiligo patients undergoing ultraviolet therapy at dermatological outpatient clinics in El- Salam and Al-Hayat hospitals, affiliated to the Egypt Health Care Authority in Port Said Government, Egypt. Employing a quasi-experimental research design, the study conducted pre-post and follow-up assessments to explore the effect of an educational program on patient knowledge and quality of life. Data collection involved two main tools: a structured interview schedule to assess patient knowledge about vitiligo and a scale to measure the quality of life among vitiligo patients. Results: In the pre-intervention phase, only 1.8% of vitiligo patients aged under 20 years had total satisfactory knowledge, whereas this increased significantly to 92.7% in the post-intervention phase, although it slightly decreased to 56.4% in the follow-up phase. The mean quality of life scores (±SD) were 2.93 ± 0.62 in the pre/post phases and 2.67 ± 0.68 in the follow-up phase. A statistically significant positive correlation was observed between the patients' knowledge levels and their quality of life across all phases of the program. Conclusion: Highly statistically significant improvements were observed immediately after the implementation phase in both the total level of knowledge and the quality of life among the studied patients. Furthermore, the educational program successfully achieved its aim of positively changing knowledge and quality of life regarding vitiligo disease. Recommendations: Continuous educational and supportive programs are recommended for vitiligo patients and their family members who are at higher risk for QoL impairment.