Postintubation-related events are a group of respiratory complications associated with tracheal intubation or extubation after general anesthesia. Few investigations have evaluated pharmacologic interventions as a means of reducing these complications. Efficiency of Intracuff Paracetamol is an area left not much explored hence this study was conducted to assess the effect of intracuff paracetamol 1.0% W/V in prevention of emergence coughing and Sorethroat. Methodology: This prospective comparative study assessed the efficacy of intracuff paracetamol (1.0% w/v) in preventing emergence coughing and sore throat post-intubation. Patients undergoing elective general anesthesia were randomly assigned to either a control group (saline-filled endotracheal tube cuff) or a paracetamol group. Postoperatively, cough and sore throat were assessed at 2, 6, and 24 hours. Results: Significant reduction in postoperative cough severity in the paracetamol group compared to the control group was noticed. No participants in the paracetamol group exhibited symptoms at 6 and 24 hours postoperatively. Similarly, the incidence of postoperative sore throat decreased significantly in the paracetamol group, with no symptoms observed at 6 and 24 hours. Conclusion: This study demonstrates that intracuff paracetamol (1.0% w/v) is effective in preventing and reducing postoperative sore throat and cough.