Background: Alopecia areata is a common disorder of unknown etiology it can be devastating to a patient’s self-esteem, self-image, and overall quality of life. Aim: Assess the effect of Nursing Intervention Protocol on Quality of Life among Patients with Alopecia Areata. Quasi-experimental research design (Study and Control) was utilized. 60 adult (male and female) patients with alopecia areata were included in the study Patient assessment sheet, Alopecia Areata patient-reported outcome, and Dermatology Life Quality Index (DLQI) questionnaires. There are statistical highly significance differences between hair regrowth and quality of life after intervention among study and control groups. There was an improvement in the study group's total knowledge than the control group after 3 months. The study group had a complete hair regrowth than the control group after 3 months . Training and educational programs need to be implemented for nurses at dermatology departments who working with alopecia patients before and during receiving alravilot ray about self-care strategies.