Mechanically ventilated patients (MVPs) admitted to intensive care units (ICUs) suffer from immobility and prolonged bed rest, which can be detrimental and have negative consequences on hemodynamic parameters. Aim: This study aims to explore the effect of passive range of motion exercise on hemodynamic parameters among patients with mechanical ventilation. Subjects and Method: The study design was quasi-experimental. A purposeful sampling of adult patients with mechanical ventilation (555) was recruited from ICUs of Egypt Health Care Authority Hospitals in Port Said City that include El-Salam hospital, Al-Zhour hospital and El-Shefaa Medical Complex. Tools of Data collection: Tool I: Patients' Health Profile that includes two parts; Part 1: Patients' personal data, Part 2: Patients' health assessment. Tool II: Hemodynamic parameters assessment. Results: this study revealed a remarkable improve in mean scores of hemodynamic parameters were noted at five minutes, twenty minutes, and sixty minutes after the implementation of the passive range-of-motion exercise with statistically significant differences. Conclusion: the present study showed a positive relation between passive range-of-motion exercise and hemodynamic parameters among patients with mechanical ventilation. Recommendation: The study suggested that the passive range-of-motion exercise were crucial for treatment of patients with mechanical ventilation and should be introduced into routine clinical practice on the ICU