Preterm infants are more susceptible to develop feeding difficulties, and attaining independent oral feeding is a necessary condition for hospital discharge. The objective of the research was to assess the effect of sensorimotor stimulation on preterm infants’ outcomes. A quasi-experimental research design was applied. Sample: A convenience sampling of 60 preterm infants. Setting: Four neonatal intensive care units included in the study's implementation in Assiut City, Egypt. Tools: Three tools were employed to obtain the required data: Preterm infant data, a premature oral feeding readiness assessment scale, and a feeding progression protocol. Method: 10% of preterm infants were involved in the pilot study to assess the sheet's applicability and clarity. Results: The results showed significant differences between the sensorimotor stimulation group and the control group regarding feeding readiness, transition time to oral feeding, and duration of hospital stay Conclusion: Sensorimotor stimulation hastened transition to full oral feeding and diminished hospital stay duration. Recommendations: Sensorimotor stimulation should become a crucial part of basic nursing care offered in NICUs to preterm infants