The corticotropin-releasing factor (CRF) family, which includes four recognised peptide hormones CRF and three urocortins (UCN 1-3) and two G protein-coupled receptors CRFR1 and CRFR2, is a well-established neuroendocrine signaling peptide that regulates physiological responses to stress via the hypothalamic-pituitary-adrenal (HPA) axis 1. CRF peptides were discovered in the brain first, but they are also found in peripheral metabolic tissues such as skeletal muscle, adipose tissue, and the pancreas2. The central and peripheral nerve systems, both of which are implicated in the neuroendocrine framework, are known to play a substantial role in stress's effects on metabolic