Background: Talent management has been advocated as an important strategy to engage and retain their employees.Talent management is essential for the organization's sustainable development, healthcare services and patients. Aim: To examine the effect of talent management training program on nurse managers' leadership effectiveness. Design: A quasi – experimental design was utilized in this study. Setting: The study was conducted in different clinical specialties units and departments at New Kasr El Aini teaching hospital affiliated to Cairo University. Subjects: A convenient sample of (55) nurse managers who are working in the selected different clinical units and department. Tools: Data werecollected by using the following fourtools: (1)Personal characteristics data sheet, (2) Talent management knowledge questionnaire, (3) Talent management practice observational checklist,(4) Leadership effectiveness practice observational checklist. Results:There was a statistical significant difference in total knowledge test scores (F = 123.5, P = 0.0001), as well as, in mean scores of total talent management practices (F = 136.4, P = 0.0001) during different periods of assessment. There was a statistical significant difference in total leadership effectivenesspractices (F = 154.0, P = 0.0001)among nurse managers during different periods of assessment. Conclusion: There was a positive effect of a talent management training program on nurse managers' leadership effectiveness. Recommendations: provide nurse managers with adequate support and needed resources that facilitate implementation of talent management as well as motivatethem to implement the new educational strategies of talent management that improve their leadership effectiveness. Replicate of the current study in other hospitals to get the talent management benefits and effectiveness for nurse managers,hospital and patients.