Male infertility is a condition in which a man is unable to conceive a child. Infertility can be caused by a variety of factors, including problems with the sperm production, delivery, or function. Male infertility is diagnosed when a man has been unable to conceive a child after one year of unprotected intercourse. Methodology: Pre-experimental one group pre-test post test was conducted to assess the knowledge regarding effect of mobile radiation on male fertility among the degree college students at selected colleges of Sangli, Miraj, Kupwad corporation area”. The reliability coefficient ‘r ’of the questionnaire was 0.88, hence it was found reliable. Total 100 samples were selected by random sampling technique. A Structured questionnaire was administered to collect data. Pre-test was given on the 1st day followed by planned teaching and Post-test was administering done on 7th day. Result: Before giving planned teaching, college students were unaware of the knowledge regarding effect of mobile radiation on male fertility. It was found maximum college students had good knowledge. A study to assess the effectiveness planned teaching program on knowledge regarding effect of mobile radiation on male fertility among the college students. The pre-test average score was 4.95 with standard deviation of 2.085. The post-test average score was 15.71 with standard deviation of 2.82. The test statistics value of the paired’ t test was -34.50 with p value 0.00 Shows that calculated value is more than table value there was significant difference in the average knowledge score, at 5%level of significance. Conclusion: Thus, it was concluded that, the study clearly indicated that there are changes in pre-test and post-test knowledge score.