This research was carried out to find the efficacy of Acapella on spirometer measures in patients experiencing acute exacerbation of bronchiectasis. Methods: Thirty patients of both gender with acute exacerbation of bronchiectasis with age ranged from 40-55 years old contributed to this research, two groups of equal size were selected at random experimental groups (n= 15), group (A) as well as group (B), Group (A) were given Acapella, that conducted through a supervised session of three sets each one of 10 repetitions, two times daily for 14 days, in addition to routine physiotherapy program(breathing exercises, postural drainage, Percussion as well as vibration), while Group (B) were given only routine physical therapy program for 14 days. Spirometer measures forced vital capacity (FVC), forced expiratory volume in the first second (FEV1) as well as FEV1/FVC were assessed for all patients before the beginning and after the end of this study. Results: Non-significant differences (p > 0.05) were found among groups (A & B) on the pre-treatment mean values regarding FVC, FEV1 and FEV1 / FVC, whereas after treatment, there were statistically substantial variations in all evaluated variables, both within and between the two groups (p < 0.05). Conclusion: Acapella is an effective device for improving spirometer measures as well as pulmonary function in patients experiencing acute exacerbation of bronchiectasis