Inspite of extensive preventive programs, in India iron-deficiency anemia during pregnancy is the most common type of anemia. This results in adverse pregnancy outcomes for both mother and newborn. The present study is done on 200 antenatal women to observe the outcome of daily versus alternate day iron supplementation during pregnancy. The results revealed that the present iron supplementation dose may not be suitable for all the pregnant women. For non-anemic women small doses may be sufficient to avoid unwanted side effects of iron supplementation. Aim: To study the efficacy of oral iron daily versus alternative day admission and its outcome during pregnancy. Methodology: A randomized clinical trial was done on 200 antenatal women attending OPD of department of Obstetrics and Gynecology, Vinayaka, Missions Medical College, Karaikal. All healthy antenatal mothers coming to antenatal OPD in VMMC&H Karaikal were included in the study. ANTENATAL Mothers with Preexisting anemia, history of chronic illness (DM, HTN, bronchial asthma, epilepsy, cardiac diseases etc.), history of menorrhagia, history of chronic peptic ulcer(hemorrhagic), history of beta thalassemia and other hemoglobinopathy, multiple pregnancy, any allergy to iron were excluded from the study. Randomization into 2 groups (40 each) was done. Baseline hemogram and ferritin were done for every subject. Investigations are repeated at 28 weeks and 36 weeks. Pregnancy outcome measure-mean birth weight and mode of delivery were compared in between the groups. CONCLUSION: Our study concluded that alternate day iron supplementation in low-risk anemic pregnant women can be done. The present iron supplementation dose may not be suitable for all the pregnant women. For non-anemic women small doses may be sufficient to avoid unwanted side effects of iron supplementation. Patient compliance can also be increased if side effects are avoided.