Enterococcus faecium (M74), a lactic acid bacterium and normal inhabitant in the gut, is a probiotic that may be useful in animal health; likewise, including E. faecium (M74) in the feed reduced the faecal concentrations of Clostridium perfringens and increased the levels of the potentially beneficial Bifidobacteria and Lactobacilli. Aim of the study: This study explores the possible use of Enterococcus Faecium (M74) probiotics as an alternative to antibiotics for treating necrotic enteritis (NE) in broilers, with the emerging public health concern about antibiotic resistance. Investigate the possible mechanism involved in the beneficial effect of suggested Enterococcus faecium (M74) on growth performance and carcass characteristics of broiler chickens via evaluating the growth performance profile, haematological profile, Liver and kidney functions, immunological response, histopathological examination of the GIT Tissue, Re-isolation of Cl. perfringens from the infected chickens I am running a few minutes late; my previous meeting is running over. post-treatment. Results: Both C. perfringens and total coliform counts were significantly the lowest in the prophylactic and treated groups. Furthermore, the prophylactic and treated groups showed significant improvement in the count compared to the positive control group. The relative length of the jejunum and ileum in control group on day 35 was significantly shorter than that in other groups. Adding E. faecium significantly reduced the relative length of the cecum on day 21. Conclusion: E.Faecium (M74) was able to significantly lesser the C. perfringens–induced Necrotic enteritis and its consequences on the growth performance, haematological picture, liver and kidney functions, immunological profile in addition to its positive impacts on the bacterial burden and histopathological picture of the gut intestine of the infected broilers. Considering the antibiotic resistance problem, E.Faecium (M74) could be used as one of the best alternatives to antibiotics in dealing with C. perfringens (NE), with special references to the preference for a prophylactic regimen over the therapeutic one