Background: There is conflicting evidence regarding the relationship between endocan and cardiovascular disease (CVD in chronic kidney diseases. The present study aimed to assess endocan and proinflammatory marker levels in Renocardio syndrome. Methodology: Out of 135 subjects, 85 were diagnosed with chronic kidney diseases, and 50 were normal healthy controls of either sex with an age group of 18-65 years. Out of 85, 45 had chronic kidney disease with cardiovascular complications, and 40 had chronic kidney disease without cardiovascular complications. Blood urea, Creatinine and hs-CRP levels were estimated by EM-200 fully automated machine. Endocan by ELISA Method. Results: The SPSS 22.0 version was used to analyze the results. Compared to patients with chronic renal failure without cardiovascular complications and the control group, blood urea, hs-CRP levels, and endocrine levels were considerably higher in the former group. The relationship between hs-CRP and endocan is positively correlated (r=0.6998). Conclusion:The study parameters' observed values emphasise how better prognosis for cardiovascular complications in individuals with chronic kidney disease correlates with risk prediction.