Allergic reactions, including asthma, rhinitis, and dermatitis, are increasingly prevalent worldwide, posing significant burdens on public health systems. Understanding the underlying molecular mechanisms driving these conditions is crucial for developing effective therapies. Epigenetic regulation, particularly through DNA methylation and histone modifications, has emerged as a key player in modulating immune responses in allergy and asthma pathogenesis. DNA methylation, the addition of a methyl group to cytosine residues within CpG dinucleotides, is a dynamic process that influences gene expression patterns. In allergic diseases, aberrant DNA methylation patterns have been observed in various immune cells, affecting the transcription of genes involved in inflammation, immune regulation, and tissue remodeling. Studies have demonstrated differential methylation profiles in individuals with allergic diseases compared to healthy controls, highlighting the role of DNA methylation in disease susceptibility and progression. Histone modifications, including acetylation, methylation, phosphorylation, and ubiquitination, play crucial roles in chromatin structure and gene expression regulation. Dysregulation of histone modification patterns has been implicated in allergic inflammation, airway hyperresponsiveness, and tissue remodeling in asthma. Histone modifying enzymes, such as histone acetyltransferases and histone deacetylases, dynamically regulate chromatin accessibility and gene expression in response to environmental stimuli, allergens, and inflammatory signals