The assay of Azelnidipine from tablet formulation was established using a straight forward and reliable method. To increase the sensitivity of the suggested UV spectrophotometry method, the solvent system and wavelength of detection were created. The present research is aimed to develop analytical procedures for Azelnidipine to analyze them by development of accurate, precise and robust in UV Spectroscopy and Reversed Phase High Performance Liquid Chromatography method. The quantitative determination of Azelnidipine using the latest UV Spectrophotometric approach was found to be accurate, sensitive, exact, and well-applied. In the RP-HPLC method, the mobile phase had a methanol to water ratio of 75:25, 0.1% glacial acetic acid, and a wave length of 257 nm. The injection volume was 20 µl. Azelnidipine was shown to have a retention time of 6.130 minutes. The statistical validation of the procedure revealed that the %RSD was < 2, indicating huge degree of accuracy and precision. With a mean correlation coefficient of 0.999, Azelnidipine exhibits a rise in absorbance at 257 nm and linearity in the concentration range of 2–12 µg/ml. This UV Spectrophotometric technique was successfully developed and validated for the assay of Azelnidipine in tablet dosage form. The approach was shown to be precise, accurate, linear, and specific. The sample retake in tablet form was in good agreement with the label claim, indicating the method's validity.