Ethnomedicinal research was first introduced in India by Janaki Ammal, in 1956, who analyzed the edible plants by certain tribes of South India. Diverse information on medicinal plants has been documented by Jain in 1963 and 1965 with the benefit of the Ministry of Environment and Forests, Govt. of India. India is one of the foremost producers of medicinal herbs that have its applicability amongst various traditional practitioners for therapy The amount of plant species having applications in numerous Indian medicines are as follows: Tibetan, 500; Siddha, 1,300; Ayurveda, 2,000; Unani, 1,000; Homeopathy, 800; Modern, 200, and folk, 4,500. History discovered that plants have a significant nutritional value, with their attribute towards therapeutic measure, and has its function in translational medicine. Alzheimer’s Disease is a chronic and advanced neurodegenerative disorder discernable by behavioral and cognitive damage that suggestively inhibits with occupational and social functioning, and is recognized with 3 clusters of early indications. The first group is the cognitive related syndrome; the second is a behavioral syndrome, and the third is a syndrome in performing daily activities. Frequently, the dearth of memory is the initial symptom that seems, though, the distant memory has healthier enactment in comparison to the short-term memory. Compounds derived from plant, such as terpenoids, polyphenols, alkaloids, glycosides, saponins, and steroids, which are regulators of neurotrophin-mediated neuroprotection. These novel classes of natural compounds would have a better safety profile since these acquire lesser side-effects as compared with synthetic compounds