Colon cancer is one of the world's most common and fatal cancers, accounting for nearly 881,000 cancer-related deaths. Progression of the colorectal Carcinoma adenoma is caused by three main ways: Microsatellite instability, chromosomal instability and CpG island methylator phenotype. A growing body of scientific evidence points to the fact that colon cancer is a heterogeneous disease; The genetic traits of tumours determine their offspring. The successful treatment of colon cancer depends on an early diagnosis and efficient targeted therapies based on the most recent understanding of the molecular features of colon cancer. The main source of the musky oil eugenol (4-allyl-2-methoxyphenol) is clove. Eugenol, S. aromaticum's main active constituent, has optimistic properties including antioxidants, anti-inflammatory and anticancer activity. The review article is based on the selective delivery and release of the plant-based anticancer compound eugenol (EUG) in colorectal cancer cells. In a variety of malignant tumours, including colon cancer, EUG is an apoptotic and anti-growth compound. Eugenol drastically reduces colon cancer stem cell population, invasion, and migration, all of which are important for tumour metastasis and medication resistance.