Oral submucous fibrosis (OSMF) is a chronic, progressive condition of the oral cavity characterized by inflammation and fibrosis of the submucosal tissues. Iron deficiency is a common finding in OSMF patients, which may contribute to the pathogenesis of the disease. Hepcidin, a key regulator of iron homeostasis, has been implicated in various fibrotic conditions. This study aimed to evaluate the effect of oral iron supplementation on serum hepcidin levels in OSMF patients.