Liver cirrhosis is a critical global health issue that significantly contributes to morbidity and mortality. One severe complication arising from cirrhosis is the development of oesophageal varices (EV), which can lead to life-threatening gastrointestinal bleeding. Traditional endoscopic examinations, although effective, are invasive and resource-intensive. This study investigates the diagnostic validity of the platelet count to spleen diameter (PC/SD) ratio as a non-invasive marker for predicting oesophageal varices in patients with liver cirrhosis. Methods: Data were collected from a clinical database, encompassing variables such as Body Mass Index (BMI), platelet count, spleen diameter, and Upper Gastrointestinal (GI) Endoscopy results. The study included 100 patients aged 18 to 80 years who underwent both ultrasonography and GI endoscopy in 2023. Correlation analysis and t-tests were employed to assess the relationships between BMI, platelet count, spleen diameter, and the presence of varices. Results: The analysis revealed weak associations between BMI, platelet count, spleen diameter, and the presence of varices. Specifically, the correlation coefficient between BMI and the presence of varices was 0.137, indicating a weak positive correlation. Similarly, the correlation between spleen diameter and platelet count was 0.126. The average platelet count for individuals with varices was slightly lower than those without varices. The study found a statistically significant correlation between platelet count and spleen diameter ratio Conclusion: The study demonstrates that while the PC/SD ratio shows some potential as a non-invasive marker, the associations between individual markers and the presence of varices are weak. These findings highlight the need for further research with larger sample sizes and additional health metrics to improve the accuracy of non-invasive diagnostic methods for oesophageal varices. Developing accessible diagnostic protocols could significantly enhance patient management in resource-limited settings