This study aimed to evaluate the reliability of the Beta angle and W angle in comparison with the ANB angle for assessing sagittal discrepancies in orthodontic patients. A total of 50 lateral cephalometric radiographs from patients with Class I and Class II division 1 malocclusion were analyzed. The mean values ± standard deviations for the Beta angle, W angle, and ANB angle were determined and compared between the two malocclusion groups. Statistical analyses including the Mann–Whitney U-test, Kruskal-Wallis test with Tukey HSD, and correlation analyses were conducted to assess the differences and associations among these angles within and between groups. The results showed significant differences in the mean values of the Beta angle and ANB angle between Class I and Class II division 1 malocclusions, with the Beta angle demonstrating a statistically significant difference. Correlation analyses revealed significant associations among the Beta angle, W angle, and ANB angle within both malocclusion groups. These findings highlight the utility of the Beta angle and W angle as potential alternatives or supplements to the ANB angle in cephalometric assessments of sagittal jaw relationships. Further research is warranted to validate these findings across diverse populations and clinical settings.