Traumatic brain injury (TBI) is a significant cause of morbidity and mortality worldwide. Electrolyte imbalances are common in TBI patients and can exacerbate their condition, leading to complications and prolonged ICU stays. This prospective observational study conducted at the Central ICU of Chirayu Medical College & Hospital aimed to evaluate the prevalence and types of electrolyte imbalances in TBI patients compared to trauma patients without head injuries. A total of 100 patients were enrolled, with 50 in each group. Blood investigations and daily monitoring of electrolyte levels were conducted. Statistical analysis revealed that TBI patients had lower levels of sodium, potassium, calcium, magnesium, phosphate, and chloride compared to the control group. These findings highlight the importance of early identification and management of electrolyte imbalances in TBI patients to improve outcomes and reduce ICU stay duration. Standardized protocols for electrolyte monitoring and tailored therapeutic strategies are essential in the critical care management of TBI patients.