Cancer and its related harmful effects on treatment techniques, such as radiation and chemotherapy, greatly diminish the quality of life for individuals suffering from the disease. Consequently, methods to control side effects caused by radiation and chemotherapy have received more attention as of late. Glycyrrhiza glabra, also known as liquorice, is a perennial herb with a long history of use in traditional medicine. Scientists have studied its possible medicinal uses at length. Liquorice and related regimens taken at the same time as chemotherapy may lessen the side effects of the latter. The efficacy of botanicals including licorice in reducing side effects of cancer treatments like radiation and chemotherapy is, however, still little understood. Our goal was to provide clear information and emphasize the possibility of using drugs derived from licorice as part of a chemotherapy treatment plan for gastrointestinal inflammations. By improving QoL, this method has the potential to increase treatment adherence. The HPTLC finger printing and marker study lends credence to the idea that GG could improve patients' well-being by decreasing chemotherapy-induced side effects, especially those pertaining to the GI system. To begin evaluating the herb's potential, this study will serve as a beginning step.