Enicostema axillare (Poir. ex Lam.) A. Raynal of the family Gentianaceae is a folk medicinal herb with excellent properties in various diseases and uses for ages. In Indian systems of medicine, it is widely used under various names viz. Mammajjak, Nagajihva, Nahi, Trunapatra, and chhota chirayata and which found in Maharashtra, Gujarat, Andhra Pradesh, Madras, and coastal parts. In rural India, decoction or juice of Nahi drink for fever, anorexia, loss of appetite, worms, and skin diseases with miraculous effects. In snake bite, the local rural people apply the paste of Nahi. Hence, they call it ‘Maay’ (mother of remedies for all diseases). This study assessed the antipyretic activity of the whole plant of Nahi (E. axillare). Nahi (Enicostemma axillare (Poir. ex. Lam.) A. Raynal) was self-collected from the natural habitat and authenticated by Agharkar Research Institute (ARI) [AUTH - 44], Pune. Preparation of Nahi churn, Kwath, and Swaras was done by standard Ayurvedic method and Physicochemical and phytochemical analyses were also carried out. Antipyretic activity tests using 20% Brewer’s yeast-induced hyperthermia in Rats were assessed. The drug formulations i.e. Panchang Swaras, Kwath, Churn & Aq. Extract have shown a high degree of antipyretic action.