Background:Female pattern hair loss (FPHL) is the most prevalent form of hair loss among women. A lot of drugs and interventions were tried but minoxidil is still the only FDA approved topical therapy. Hormonal therapy in the form of topical estradiolis commonly used in Europe and South Korea. The aim of our study is to evaluate the role of topical estradiol in treating FPHl in previous studies. Methods:A thorough literature search of topical estradiol in treating female androgenic alopecia using PubMed was conducted, and all references related to hair loss were reviewed. This study was conducted at the department of Dermatology and Andrology, Helwan University from 2022 till 2023.Results: Few clinical trials were conducted using topical estradiol either alone or in combination with topical minoxidil. Topical estradiol showed efficacy in stabilization of hair loss, increasing hair density and thickness in some clinical trials. Conclusion: More studies are needed to evaluate if adding topical estradiol to minoxidil in treating FPHL is more effective and to evaluate its safety.