Background: The goal of this research was to find out if Celosia leptostachyahas anticonvulsant properties using Pentylenetetrazole (PTZ), Brucine (BRC), and Maximal electroshock (MES) induced seizures in mice. Materials andMethods: PTZ, BRC, and MES induced seizures in mice were used. Group1 received normal saline, Goup5 received standard drugs while Groups 2, 3 and 4, were respectively treated with 100, 150 and 200 mg/kg of the extract. The sedative-hypnotic behaviour was assayed using diazepam-induced sleep. Results: In MES-induced seizures, ethanol extract of Celosia leptostachya(EECL) at 100 mg/kg, 150 mg/kg, and 200 mg/kg protected the animals against hind limb tonic extension and also, in convulsed mice significantly (P< 0.05) decreased mean recovery time suggesting inhibition of Na+ gated channels. In BR-induced seizures, EECL at 150 and 200 mg/kg offered protection against mortality but did not significantly (P>0.05) affect both the mean onset time and mean duration of convulsion. In PTZ-induced seizures, EECL at 200 mg/kg offered protection against mortality and significantly (P<0.05) attenuated both mean onset time and mean duration of convulsion suggesting activity on GABAA receptors. The EECL 100, 150, and 200 mg/kg doses significantly (P < 0.05) prolonged the total duration of Diazepam-induced sleeping time in mice without affecting the mean onset of sleep, indicating sedative action of the extract.